Tpcn2^tm1.1Cwsc
Targeted Allele Detail

Summary

• Symbol: Tpcn2^tm1.1Cwsc
• Name: two pore segment channel 2; targeted mutation 1.1, Christian Wahl-Schott
• MGI ID: MGI:5707829
• Gene: Tpcn2 Location: Chr7:144740261-144837748 bp, - strand Genetic Position: Chr7, 89.02 cM
• Alliance: Tpcn2^tm1.1Cwsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225206
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exon 7 and the selection cassette. (J:225206)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpcn2 Mutation: 53 strains or lines available

References

• Original: J:225206 Grimm C, et al., High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nat Commun. 2014;5:4699
• All: 2 reference(s)