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Fmo5tm1Eshe
Targeted Allele Detail
Nomenclature
Symbol: Fmo5tm1Eshe
Name: flavin containing monooxygenase 5; targeted mutation 1, Elizabeth A Shephard
MGI ID: MGI:5707817
Synonyms: Fmo5-
Gene: Fmo5  Location: Chr3:97628804-97655282 bp, + strand  Genetic Position: Chr3, 42.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:223365
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced by a neomycin resistance cassette. Western blot of liver proteins showed a lack of encoded protein expression in homozygous mutant mice compared with control mice. (J:223365)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fmo5 Mutation:  0 strains or lines available
References
Original:  J:223365 Gonzalez Malagon SG, et al., The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Biochem Pharmacol. 2015 Aug 1;96(3):267-77
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory