Trp73^tm1.2Elrf
Targeted Allele Detail

Summary

• Symbol: Trp73^tm1.2Elrf
• Name: transformation related protein 73; targeted mutation 1.2, Elsa R Flores
• MGI ID: MGI:5707753
• Synonyms: deltaNp73^-
• Gene: Trp73 Location: Chr4:154140706-154224332 bp, - strand Genetic Position: Chr4, 83.79 cM
• Alliance: Trp73^tm1.2Elrf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218385
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3' and an FRT site flanked neomycin resistance gene cassette and loxP site were inserted downstream of exon 3'. The neo cassette was removed through subsequent flp-mediated recombination. The floxed exon 3' was deleted through cre-mediated recombination. This deletion specifically knocks out the specific deltaN isoform that uses an alternative exon 3 that lacks the acidic transactivation domain sequence. (J:218385)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp73 Mutation: 47 strains or lines available

References

• Original: J:218385 Venkatanarayan A, et al., IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature. 2015 Jan 29;517(7536):626-30
• All: 1 reference(s)