Gt(ROSA)26Sor^{tm1(CMV/ACTB-Cnr1,-EGFP)Nst}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CMV/ACTB-Cnr1,-EGFP)Nst}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Nephi Stella
• MGI ID: MGI:5707648
• Synonyms: R26^fsCB1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CMV/ACTB-Cnr1,-EGFP)Nst} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218315
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CMV/ACTB-Cnr1,-EGFP)Nst} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cnr1 (MGI:104615)

• Mutation details: A construct consisting of a hybrid CMV and chicken beta-actin promoter, floxed stop cassette, mouse Cnr1 open reading frame, IRES, and EGFP gene was inserted into the locus via homologous recombination. (J:218315)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:218315 Naydenov AV, et al., Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice. Neurobiol Dis. 2014 Nov;71:140-50
• All: 2 reference(s)