Ramp1^tm1.1Kmca
Targeted Allele Detail

Summary

• Symbol: Ramp1^tm1.1Kmca
• Name: receptor (calcitonin) activity modifying protein 1; targeted mutation 1.1, Kathleen M Caron
• MGI ID: MGI:5707075
• Gene: Ramp1 Location: Chr1:91107544-91152918 bp, + strand Genetic Position: Chr1, 46.08 cM
• Alliance: Ramp1^tm1.1Kmca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218915
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the selection cassette. RT-PCR confirmed the absence of transcript expression in the brain. (J:218915)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ramp1 Mutation: 19 strains or lines available

References

• Original: J:218915 Li M, et al., Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice. PLoS One. 2014;9(7):e102356
• All: 8 reference(s)