Col1a1^{tm1(CAG-Nampt)Jbau}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(CAG-Nampt)Jbau}
• Name: collagen, type I, alpha 1; targeted mutation 1, Joseph A Baur
• MGI ID: MGI:5706806
• Synonyms: Nampt^fl
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(CAG-Nampt)Jbau} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217886
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Col1a1^{tm1(CAG-Nampt)Jbau} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Nampt

• Mutation details: A CAGGS promoter, floxed stop cassette and Nampt cDNA were inserted in the 3' UTR via homologous recombination. (J:217886)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 166 strains or lines available

References

• Original: J:217886 Frederick DW, et al., Increasing NAD Synthesis in Muscle via Nicotinamide Phosphoribosyltransferase Is Not Sufficient to Promote Oxidative Metabolism. J Biol Chem. 2015 Jan 16;290(3):1546-58
• All: 3 reference(s)