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Plxnb2tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Plxnb2tm1c(EUCOMM)Wtsi
Name: plexin B2; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5706788
Synonyms: Plexin-B2fl
Gene: Plxnb2  Location: Chr15:89155549-89180788 bp, - strand  Genetic Position: Chr15, 44.68 cM, cytoband E3
Mutation
origin
Mutant Cell Line:  EPD0051_2_D09
Germline Transmission:  Earliest citation of germline transmission: J:228347
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_st1
 
Mutation detailsThe L1L2_st1 cassette was inserted at position 89165019 of Chromosome 15 upstream of the critical exons 7-9 (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 7-9 at position 89163751. The critical exons 7-9 are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:228347)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plxnb2 Mutation:  60 strains or lines available
References
Original:  J:228347 Daviaud N, et al., Impaired cortical neurogenesis in plexin-B1 and -B2 double deletion mutant. Dev Neurobiol. 2016 Aug;76(8):882-99
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory