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Ngly1tm1.1Tasuz
Targeted Allele Detail
Nomenclature
Symbol: Ngly1tm1.1Tasuz
Name: N-glycanase 1; targeted mutation 1.1, Tadashi Suzuki
MGI ID: MGI:5705596
Gene: Ngly1  Location: Chr14:16249314-16311926 bp, + strand  Genetic Position: Chr14, 7.08 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:217663
Parent Cell Line:  KY1.1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 11 and an FRT flanked neo cassette and loxP site were inserted downstream of exon12 via homologous recombination. Cre mediated recombination removed exons 11 and 12 and the neo cassette. (J:217663)
Generation of the Ngly1tm1Tasuz and Ngly1tm1.1Tasuz alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ngly1 Mutation:  7 strains or lines available
References
Original:  J:217663 Huang C, et al., Endo-beta-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1398-403
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory