Usp16^tm2.1Hbwg
Targeted Allele Detail

Summary

• Symbol: Usp16^tm2.1Hbwg
• Name: ubiquitin specific peptidase 16; targeted mutation 2.1, Hengbin Wang
• MGI ID: MGI:5705306
• Synonyms: Usp16^2lox
• Gene: Usp16 Location: Chr16:87251833-87280403 bp, + strand Genetic Position: Chr16, 49.54 cM, cytoband C3.3
• Alliance: Usp16^tm2.1Hbwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225221
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked selection cassette with a 3' loxP site were inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette and left exons 5 and 6 floxed. (J:225221)

Expression

In Mice Carrying this Mutation:

38 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Usp16 Mutation: 42 strains or lines available

References

• Original: J:225221 Yang W, et al., The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment. Nat Commun. 2014;5:3818
• All: 3 reference(s)