Stat1^tm2.1Bstr
Targeted Allele Detail

Summary

• Symbol: Stat1^tm2.1Bstr
• Name: signal transducer and activator of transcription 1; targeted mutation 2.1, Birgit Strobl
• MGI ID: MGI:5705232
• Synonyms: Stat1^beta
• Gene: Stat1 Location: Chr1:52158599-52201024 bp, + strand Genetic Position: Chr1, 26.81 cM
• Alliance: Stat1^tm2.1Bstr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221627
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: The targeting vector introduced into exon 19 the cDNA for the terminal portion of the beta isoform, a human beta-globin splice and floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. (J:221627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stat1 Mutation: 72 strains or lines available

References

• Original: J:221627 Semper C, et al., STAT1beta is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity. Mol Cell Biol. 2014 Jun;34(12):2235-48
• All: 2 reference(s)