Sim2^tm1.1Ylee
Targeted Allele Detail

Summary

• Symbol: Sim2^tm1.1Ylee
• Name: single-minded family bHLH transcription factor 2; targeted mutation 1.1, Ying-Hue Lee
• MGI ID: MGI:5703973
• Gene: Sim2 Location: Chr16:93885963-93927891 bp, + strand Genetic Position: Chr16, 55.05 cM, cytoband C3.3-C4
• Alliance: Sim2^tm1.1Ylee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227825
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP-flanked neomycin cassette was inserted into intron 1 followed by a third loxP sequence in between 5' UTR and the translation start site in exon 1. The neomycin cassette and exon 1 were removed in this allele. (J:227825)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sim2 Mutation: 23 strains or lines available

References

• Original: J:227825 Chen KJ, et al., SIM2 maintains innate host defense of the small intestine. Am J Physiol Gastrointest Liver Physiol. 2014 Dec 1;307(11):G1044-56
• All: 1 reference(s)