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Smc2tm1.1Itl
Targeted Allele Detail
Nomenclature
Symbol: Smc2tm1.1Itl
Name: structural maintenance of chromosomes 2; targeted mutation 1.1, inGenious Targeting Laboratory
MGI ID: MGI:5703878
Synonyms: Smc2flox
Gene: Smc2  Location: Chr4:52439243-52488260 bp, + strand  Genetic Position: Chr4, 28.31 cM, cytoband B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:222181
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA frt site, a loxP site, a neomycin selection cassette, a frt site, and a loxP site upstream of exon 10 and a loxP site downstream of exon 12 were inserted via homologous recombination. The neomycin selection cassette was removed via flp-mediated recombination. (J:222181)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smc2 Mutation:  5 strains or lines available
References
Original:  J:222181 Nishide K, et al., Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. PLoS Genet. 2014 Dec;10(12):e1004847
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory