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Tg(Prnp-MAPT*R406W)21807Dwst
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-MAPT*R406W)21807Dwst
Name: transgene insertion 21807, David Westaway
MGI ID: MGI:5703730
Synonyms: TgTauR406W
Transgene: Tg(Prnp-MAPT*R406W)21807Dwst  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-MAPT*R406W)21807Dwst expresses 1 gene
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
The Syrian hamster prion protein promoter drives the expression of the longest form of the human four-repeat tau with the R406W mutation. Lines 21807, 21783, and 21768 were established. RT-PCR confirmed expression of mRNA in the brain and Western blot analysis shows that expression level is about 80% that of the endogenous mouse levels.
References
Original:  J:95971 Ikeda M, et al., Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. Am J Pathol. 2005 Feb;166(2):521-31
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory