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Hic2Gt(E225A08)1.1Wrst
Gene trapped Allele Detail
Nomenclature
Symbol: Hic2Gt(E225A08)1.1Wrst
Name: hypermethylated in cancer 2; gene trap E225A08, 1.1, German Gene Trap Consortium
MGI ID: MGI:5703657
Synonyms: HicFL
Gene: Hic2  Location: Chr16:17233587-17263430 bp, + strand  Genetic Position: Chr16, 10.68 cM, cytoband B1
Mutation
origin
Mutant Cell Line:  E225A08
Germline Transmission:  Earliest citation of germline transmission: J:225226
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (No functional change)
Mutation:    Insertion of gene trap vector     Vector: rsFROSAbgeo+2s
 
Mutation detailsHic2Gt(E225A08)Wrst mice were crossed to a ubiquitously expressed ActB-Flpe transgenic line. This inverts the genetrap, inactivating the splice acceptor, and a wild-type transcript is expressed. (J:225226)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hic2 Mutation:  254 strains or lines available
References
Original:  J:225226 Dykes IM, et al., HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circ Res. 2014 Jun 20;115(1):23-31
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory