Kazn^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Kazn^{tm1c(EUCOMM)Wtsi}
• Name: kazrin, periplakin interacting protein; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5703033
• Synonyms: Kazn^fl
• Gene: Kazn Location: Chr4:141829701-142205056 bp, - strand Genetic Position: Chr4, 75.46 cM
• Alliance: Kazn^{tm1c(EUCOMM)Wtsi} page
• IMPC: Kazn gene page

Mutation origin

• Mutant Cell Line: EPD0157_6_B09
• Germline Transmission: Earliest citation of germline transmission: J:226589
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: Heterozygous Kazn^{tm1a(EUCOMM)Wtsi} mice were mated with 129S4/SvJaeSor-Gt(ROSA)26Sor^tm1(FLP1)Dym/J mice (C57BL/6J; Jackson Laboratory, Bar Harbor, ME) to remove the FRT-En2-IRES-BGal-loxP-Neo-pA cassette from intron 4, leaving loxP sites flanking exon 5. (J:226589)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kazn Mutation: 98 strains or lines available

References

• Original: J:226589 Chhatriwala MK, et al., Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis. J Invest Dermatol. 2012 Aug;132(8):1977-87
• All: 1 reference(s)