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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(GNAQ*)Cvr
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, C V Rao
MGI ID: MGI:5702870
Synonyms: Rosa26-fs-GNAQ-Q209L
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:225597
Parent Cell Line:  iTL BA1 (ES Cell)
Strain of Origin:  (C57BL/6NTac x 129S6/SvEvTac)F1
Allele Type:    Targeted (Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm1(GNAQ*)Cvr expresses 1 gene
Mutation detailsA targeting vector was designed with a minimal adenovirus type 2 major late splice acceptor, a loxP-flanked Neo-STOP cassette, a cDNA sequence encoding human GNAQ* (a mutant form of GNAQ rendered constitutively active by substitution of Glutamine 209 for Leucine (Q209L), and a bovine growth hormone polyadenylation signal. (J:225597)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  429 strains or lines available
Original:  J:225597 Huang JL, et al., Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in Mice. Cancer Res. 2015 Aug 15;75(16):3384-97
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory