Col1a1^{tm1(tetO-EGFP,-MIR26A2)Jtm}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(tetO-EGFP,-MIR26A2)Jtm}
• Name: collagen, type I, alpha 1; targeted mutation 1, Joshua T Mendell
• MGI ID: MGI:5702858
• Synonyms: Col1a1^{tm1(tetO-EGFP,-MIR26A1)Jtm}, LSL.eGFP.miR-26a
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(tetO-EGFP,-MIR26A2)Jtm} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217396
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Col1a1^{tm1(tetO-EGFP,-MIR26A2)Jtm} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MIR26A2 (407016)

  Mir26a-2

  (MGI:3619045)

• Col1a1^{tm1(tetO-EGFP,-MIR26A2)Jtm} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	tetO

• Mutation details: A construct containing a TRE, lox-stop-lox cassette, GFP, and a human pre-MIR26A2 sequence with ~100 bp of flanking sequence was inserted downstream of the coding region via homologous recombination. (J:217396)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 161 strains or lines available

References

• Original: J:217396 Zeitels LR, et al., Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis. Genes Dev. 2014 Dec 1;28(23):2585-90
• All: 2 reference(s)