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Mir182tm1.1Dgk
Targeted Allele Detail
Nomenclature
Symbol: Mir182tm1.1Dgk
Name: microRNA 182; targeted mutation 1.1, David Kirsch
MGI ID: MGI:5702430
Synonyms: miR-182-flox
Gene: Mir182  Location: Chr6:30165917-30165991 bp, - strand  Genetic Position: Chr6, 12.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:217635
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting vector is designed to insert a loxP site upstream of the Mir182 coding region and a FRT-flanked neomycin resistance (neo) cassette downstream of the coding region followed by a second loxP site. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:217635)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mir182 Mutation:  9 strains or lines available
References
Original:  J:217635 Sachdeva M, et al., MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. J Clin Invest. 2014 Oct;124(10):4305-19
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory