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Ntn5tm1.1Rwb
Targeted Allele Detail
Nomenclature
Symbol: Ntn5tm1.1Rwb
Name: netrin 5; targeted mutation 1.1, Robert W Burgess
MGI ID: MGI:5701693
Gene: Ntn5  Location: Chr7:45684022-45694556 bp, + strand  Genetic Position: Chr7, 29.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227617
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsExons 2-6 were replaced with a cassette encoding a farnysylated YFP fused to the 5-prime sequence of exon2 and an FRT-flanked neomycin resistance cassette, and subsequent flpe-mediated excision deleted the neomycin selection cassette. Although sequencing confirmed that the integrated YFPF is in-frame with the start site, no expression was detected by either endogenous fluorescence or antibody staining. Although this deletion is also in intron 1 of Sec1, Q-RT-PCR did not detect any reduction in Sec1 expression. (J:227617)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 41 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntn5 Mutation:  11 strains or lines available
References
Original:  J:227617 Garrett AM, et al., Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse. Front Mol Neurosci. 2016;9:3
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory