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Targeted Allele Detail
Symbol: S1pr3tm1.1Hrose
Name: sphingosine-1-phosphate receptor 3; targeted mutation 1.1, Hugh Rosen
MGI ID: MGI:5701466
Synonyms: S1P3-mCherry
Gene: S1pr3  Location: Chr13:51408639-51422797 bp, + strand  Genetic Position: Chr13, 26.12 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:227542
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
Mutation detailsThe targeting vector is designed to insert a monomeric red fluorescent protein (mCherry) gene and an loxP-flanked ACN cassette downstream of the coding region of the gene. Cre-mediated recombination removed the cassette leaving a single loxP site downstream of the coding region. (J:227542)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any S1pr3 Mutation:  5 strains or lines available
Original:  J:227542 Sanna MG, et al., Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. Mol Pharmacol. 2016 Jan;89(1):176-86
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory