Dchs2^tm1.2Fhel
Targeted Allele Detail

Summary

• Symbol: Dchs2^tm1.2Fhel
• Name: dachsous cadherin related 2; targeted mutation 1.2, Francoise Helmbacher
• MGI ID: MGI:5700381
• Gene: Dchs2 Location: Chr3:83035255-83264516 bp, + strand Genetic Position: Chr3, Syntenic
• Alliance: Dchs2^tm1.2Fhel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226938
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A conditional allele (Dchs2) was first generated by flanking the coding part of the last exon, encompassing the transmembrane and intracellular domains of Dchs2, with loxP sites. Mice carrying this constitutively deleted allele (Dchs2) were produced by crossing the former with a germline- active deleter-cre mouse line [Tg(CMV-cre)1Cgn]. (J:226938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dchs2 Mutation: 78 strains or lines available

References

• Original: J:226938 Bagherie-Lachidan M, et al., Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. Development. 2015 Aug 1;142(15):2564-73
• All: 1 reference(s)