Tg(SOD1*H46R)IAra
Transgene Detail

Summary

• Symbol: Tg(SOD1*H46R)IAra
• Name: transgene insertion I, Toshiyuki Araki
• MGI ID: MGI:5699320
• Synonyms: H46R (I)
• Transgene: Tg(SOD1*H46R)IAra Location: unknown
• Alliance: Tg(SOD1*H46R)IAra page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*H46R)IAra expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: A 12 kb genomic fragment containing the entire human SOD1 gene was mutated so that the histidine residue at position 46 was replaced by arginine. Nine lines were established, including lines H, I, and L. This line has 51-67 copy numbers of the transgene. (J:221350)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:221350 Nagano S, et al., A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS. Hum Mol Genet. 2015 Jun 15;24(12):3427-39
• All: 1 reference(s)