Prkcd^tm1.1Chou
Targeted Allele Detail

Summary

• Symbol: Prkcd^tm1.1Chou
• Name: protein kinase C, delta; targeted mutation 1.1, Wen-Hai Chou
• MGI ID: MGI:5699182
• Synonyms: AS-PKCdelta
• Gene: Prkcd Location: Chr14:30317311-30348167 bp, - strand Genetic Position: Chr14, 18.82 cM
• Alliance: Prkcd^tm1.1Chou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217880
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct was designed to insert a loxP-flanked neomycin (neo) resistance cassette downstream of exon 13 of the gene. A point mutation, M425A, is introduced in exon 13, which encodes a key residue for determining the selectivity of PKC inhibitors. Cre-mediated recombination removed the floxed neo cassette. (J:217880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkcd Mutation: 52 strains or lines available

References

• Original: J:217880 Kumar V, et al., Generation and Characterization of ATP Analog-specific Protein Kinase Cdelta. J Biol Chem. 2015 Jan 23;290(4):1936-51
• All: 2 reference(s)