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Targeted Allele Detail
Symbol: Prkcdtm1.1Chou
Name: protein kinase C, delta; targeted mutation 1.1, Wen-Hai Chou
MGI ID: MGI:5699182
Synonyms: AS-PKCdelta
Gene: Prkcd  Location: Chr14:30595354-30626210 bp, - strand  Genetic Position: Chr14, 18.82 cM
Germline Transmission:  Earliest citation of germline transmission: J:217880
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsThe targeting construct was designed to insert a loxP-flanked neomycin (neo) resistance cassette downstream of exon 13 of the gene. A point mutation, M425A, is introduced in exon 13, which encodes a key residue for determining the selectivity of PKC inhibitors. Cre-mediated recombination removed the floxed neo cassette. (J:217880)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkcd Mutation:  11 strains or lines available
Original:  J:217880 Kumar V, et al., Generation and Characterization of ATP Analog-specific Protein Kinase Cdelta. J Biol Chem. 2015 Jan 23;290(4):1936-51
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory