Ltbp2^tm1.1Tynk
Targeted Allele Detail

Summary

• Symbol: Ltbp2^tm1.1Tynk
• Name: latent transforming growth factor beta binding protein 2; targeted mutation 1.1, Tomoyuki Nakamura
• MGI ID: MGI:5698974
• Synonyms: Ltbp2^flox
• Gene: Ltbp2 Location: Chr12:84829986-84923306 bp, - strand Genetic Position: Chr12, 39.39 cM, cytoband D
• Alliance: Ltbp2^tm1.1Tynk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214736
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The exon 1 coding sequence was flanked by two loxP sequences inserted in the 5' untranslated region of exon 1 and in intron 1. A FRT-flanked neomycin selection cassette located 3' to the loxP site in intron 1 was deleted via Flp-mediated recombination. (J:214736)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltbp2 Mutation: 116 strains or lines available

References

• Original: J:214736 Inoue T, et al., Latent TGF-beta binding protein-2 is essential for the development of ciliary zonule microfibrils. Hum Mol Genet. 2014 Nov 1;23(21):5672-82
• All: 1 reference(s)