Sdk2^{tm1.1(cre/ERT2)Jrs}
Targeted Allele Detail

Summary

• Symbol: Sdk2^{tm1.1(cre/ERT2)Jrs}
• Name: sidekick cell adhesion molecule 2; targeted mutation 1.1, Joshua R Sanes
• MGI ID: MGI:5698883
• Synonyms: Sdk2^ce
• Gene: Sdk2 Location: Chr11:113667200-113957855 bp, - strand Genetic Position: Chr11, 79.3 cM
• Alliance: Sdk2^{tm1.1(cre/ERT2)Jrs} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225578
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Sdk2^{tm1.1(cre/ERT2)Jrs} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sdk2 (MGI:2443847)

• Mutation details: The first coding exon was replaced with an inducible cre recombinase gene (cre/ERT2) epitope tagged with six tandem copies of the Myc tag. Cre-mediated recombination removed the floxed neomycin resistance cassette. Immunohistochemistry confirmed the absence of protein expression in the retina from P30. (J:225578)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sdk2 (mouse) Summary of all recombinase alleles driven by Sdk2. Alliance mouse Sdk2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sdk2 Mutation: 119 strains or lines available

References

• Original: J:225578 Krishnaswamy A, et al., Sidekick 2 directs formation of a retinal circuit that detects differential motion. Nature. 2015 Aug 27;524(7566):466-70
• All: 6 reference(s)