Slc25a12^{tm1a(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Slc25a12^{tm1a(EUCOMM)Hmgu}
• Name: solute carrier family 25 (mitochondrial carrier, Aralar), member 12; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5698859
• Gene: Slc25a12 Location: Chr2:71104614-71198125 bp, - strand Genetic Position: Chr2, 42.38 cM
• IMPC: Slc25a12 gene page

Mutation origin

• Mutant Cell Lines: HEPD1054_4_A02, HEPD1054_4_B02, HEPD1054_4_B03, HEPD1054_4_B05, HEPD1054_4_C02, HEPD1054_4_C03, HEPD1054_4_C04, HEPD1054_4_C05, HEPD1054_4_D03, HEPD1054_4_D04, HEPD1054_4_E04, HEPD1054_4_E05, HEPD1054_4_F02, HEPD1054_4_F04, HEPD1054_4_G02, HEPD1054_4_G03, HEPD1054_4_G04, HEPD1054_4_G05, HEPD1054_4_H02, HEPD1054_4_H03, HEPD1054_4_H04
• Germline Transmission: Unknown
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 71173976 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 71174796. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc25a12 Mutation: 101 strains or lines available

References

• Original: J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015
• All: 1 reference(s)