Mapt^tm1.1Lngn
Targeted Allele Detail

Summary

• Symbol: Mapt^tm1.1Lngn
• Name: microtubule-associated protein tau; targeted mutation 1.1, Lars NG Nilsson
• MGI ID: MGI:5698834
• Synonyms: E10^-
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm1.1Lngn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221311
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: A loxP-flanked neomycin selection cassette replaced a genomic fragment containing exon 10. The neomycin cassette was removed via Cre-mediated recombination. This allele mis-expresses the 3R-tau isoform after P18 in heterozygous and homozygous mice, when it is not seen in wild-type mice. 4R-tau isoform expression is unaffected. (J:221311)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 453 strains or lines available

References

• Original: J:221311 Gumucio A, et al., Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging. BMC Neurosci. 2013;14:148
• All: 1 reference(s)