Terf1^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Terf1^tm1.1Geno
• Name: telomeric repeat binding factor 1; targeted mutation 2.1, Genoway
• MGI ID: MGI:5698821
• Synonyms: eGFPTRF1^KI
• Gene: Terf1 Location: Chr1:15875870-15914276 bp, + strand Genetic Position: Chr1, 4.88 cM, cytoband E3
• Alliance: Terf1^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225055
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An eGFP-expression construct was inserted behind the ATG start codon in the first exon. A loxP-flanked neomycin selection cassette was inserted into intron 1. The neomycin cassette was removed via Cre-mediated recombination. This allele expresses a eGFP-Tref1 fusion protein with colocalizes with endogenous gene product at telomeres. (J:225055)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Terf1 Mutation: 37 strains or lines available

References

• Original: J:225055 Schneider RP, et al., TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells. Nat Commun. 2013;4:1946
• All: 1 reference(s)