Rab18^m1Hongc
Chemically induced Allele Detail

Summary

• Symbol: Rab18^m1Hongc
• Name: RAB18, member RAS oncogene family; mutation 1, Chen-Jee Hong
• MGI ID: MGI:5698701
• Synonyms: Rab18^-
• Gene: Rab18 Location: Chr18:6765167-6791606 bp, + strand Genetic Position: Chr18, 4.53 cM
• Alliance: Rab18^m1Hongc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This ENU-induced mutation was isolated in a screen for abnormal behavior at the Mouse Mutagenesis Program Core Facility in Academia Sinica, Taiwan. A 7827-bp deletion spanning the promoter region, exon 1, and a part of intron1 in the Rab18 gene was identified. Western blot confirmed absence of protein in the cerebellum of homozygotes. (J:220974)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab18 Mutation: 24 strains or lines available

References

• Original: J:220974 Cheng CY, et al., ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18. Exp Neurol. 2015 May;267:143-51
• All: 2 reference(s)