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Tg(Prnp-CRYAB)Z104Dbo
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-CRYAB)Z104Dbo
Name: transgene insertion Z104, David R Borchelt
MGI ID: MGI:5697709
Synonyms: Z104
Transgene: Tg(Prnp-CRYAB)Z104Dbo  Location: unknown  
Transgene
origin
Strain of Origin:  (C3H/HeJ x C57BL/6J)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-CRYAB)Z104Dbo expresses 1 gene
 
Mutation detailsThe transgenic construct contains cDNA of human alpha B crystallin under the control of the mouse Prnp, prion protein, gene promoter. The 6 kb promoter consists of the first exon, the first intron, and the fused 2nd and 3rd exons. Expression of the transgene is observed in the forebrain, cerebellum, spinal cord and kidney. No evidence of expression was found in lung, spleen, testes or liver. (J:226527)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:226527 Xu G, et al., Substantially elevating the levels of alphaB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation. J Neurochem. 2015 May;133(3):452-64
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory