Auts2^tm1Dare
Targeted Allele Detail

Summary

• Symbol: Auts2^tm1Dare
• Name: autism susceptibility candidate 2; targeted mutation 1, Danny Reinberg
• MGI ID: MGI:5697525
• Gene: Auts2 Location: Chr5:131466171-132572059 bp, - strand Genetic Position: Chr5, 70.66 cM, cytoband G1
• Alliance: Auts2^tm1Dare page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217675
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: Two LoxP sites were placed flanking exon 7 of the gene. A cassette containing SAIREStdTomato and an inverted PGKNeo (neomycin phosphotransferase gene) were flanked by two FRT (FLP recombinase target) sites and inserted between the first LoxP site and exon 7. A WPRE (woodchuck hepatitis post-transcriptional regulatory element) sequence was placed immediately downstream of tdTomato to enhance its expression. (J:217675)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Auts2 Mutation: 64 strains or lines available

References

• Original: J:217675 Gao Z, et al., An AUTS2-Polycomb complex activates gene expression in the CNS. Nature. 2014 Dec 18;516(7531):349-54
• All: 1 reference(s)