Gt(ROSA)26Sor^{tm2(CAG-tdTomato,cAMPRE-luc)Berd}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-tdTomato,cAMPRE-luc)Berd}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Rebecca Berdeaux
• MGI ID: MGI:5696733
• Synonyms: ROSA26-CRE-luc
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-tdTomato,cAMPRE-luc)Berd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236221
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted into the locus a CAG promoter, floxed STOP cassette, dTomato reporter gene, and cAMP responsive element (cAMPRE) that drives cAMP-activated expression of the luciferase reporter gene. (J:236221)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

Notes

Up to 10% of mice never show substantial bioluminescence in any tissue and/or do not respond to fasting. J:236221

References

• Original: J:236221 Akhmedov D, et al., Knock-in Luciferase Reporter Mice for In Vivo Monitoring of CREB Activity. PLoS One. 2016;11(6):e0158274
• All: 1 reference(s)