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Tg(Cd74-Nlrc4*)1Kyas
Transgene Detail
Nomenclature
Symbol: Tg(Cd74-Nlrc4*)1Kyas
Name: transgene insertion 1, Koji Yasutomo
MGI ID: MGI:5696384
Synonyms: mu-Nlrc4
Transgene: Tg(Cd74-Nlrc4*)1Kyas  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Cd74-Nlrc4*)1Kyas expresses 1 gene
 
Mutation detailsThe mouse Nlrc4 cDNA with a mutation equivalent to the human A to C transversion at position 1589 in exon 4 (changing a histidine to a proline at position 443) and three HA tags is under the control of an invariant chain promoter. Three lines were created: 1, 2, and 3. Line one shows an approximate 3.1-fold increase in Nlrc4 levels in the spleen compared to endogenous levels. (J:219652)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:219652 Kitamura A, et al., An inherited mutation in NLRC4 causes autoinflammation in human and mice. J Exp Med. 2014 Nov 17;211(12):2385-96
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory