Col1a1^{tm3(CAG-IDH2*R172K)Nbar}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm3(CAG-IDH2*R172K)Nbar}
• Name: collagen, type I, alpha 1; targeted mutation 3, Nabeel Bardeesy
• MGI ID: MGI:5695656
• Synonyms: LSL-IDH2^R172K
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm3(CAG-IDH2*R172K)Nbar} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217109
• Parent Cell Line: C2 (Jaenisch) (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Col1a1^{tm3(CAG-IDH2*R172K)Nbar} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IDH2 (3418)

  Idh2	(MGI:96414)

• Mutation details: A construct containing a CAGGS promoter, a floxed stop cassette and a human IDH2 cDNA with a p.R172K mutation was inserted into the FRT site flanked docking site downstream of the gene . (J:217109)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 166 strains or lines available

Notes

C2 (Jaenisch) ES cells are derived from ES cell line v6.5.

References

• Original: J:217109 Saha SK, et al., Mutant IDH inhibits HNF-4alpha to block hepatocyte differentiation and promote biliary cancer. Nature. 2014 Sep 4;513(7516):110-4
• All: 1 reference(s)