Eng^{tm1.1(ENG)Ros}
Targeted Allele Detail

Summary

• Symbol: Eng^{tm1.1(ENG)Ros}
• Name: endoglin; targeted mutation 1.1, Roswell Park Cancer Institute
• MGI ID: MGI:5695560
• Synonyms: hue4-8ge
• Gene: Eng Location: Chr2:32536607-32572681 bp, + strand Genetic Position: Chr2, 22.09 cM
• Alliance: Eng^{tm1.1(ENG)Ros} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217024
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Eng^{tm1.1(ENG)Ros} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ENG (2022)

  Eng	(MGI:95392)

  Exons 4-8 of the human gene are fused to the endogenous mouse gene

• Mutation details: Endogenous sequence encoding exons 4-8 were replaced with sequence encoding human exons 4-8 and a floxed neo cassette was inserted in intron 8 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:217024)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eng Mutation: 44 strains or lines available

References

• Original: J:217024 Toi H, et al., Facilitation of endoglin-targeting cancer therapy by development/utilization of a novel genetically engineered mouse model expressing humanized endoglin (CD105). Int J Cancer. 2015 Jan 15;136(2):452-61
• All: 1 reference(s)