Casr^tm1.1Mrpk
Targeted Allele Detail

Summary

• Symbol: Casr^tm1.1Mrpk
• Name: calcium-sensing receptor; targeted mutation 1.1, Martin R Pollak
• MGI ID: MGI:5695272
• Gene: Casr Location: Chr16:36314058-36382503 bp, - strand Genetic Position: Chr16, 25.57 cM
• Alliance: Casr^tm1.1Mrpk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225084
• Parent Cell Line: C1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the selection cassette. Western blot analysis confirmed the absence of protein expresison in the kidney. (J:225084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casr Mutation: 60 strains or lines available

References

• Original: J:225084 Toka HR, et al., Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J Am Soc Nephrol. 2012 Nov;23(11):1879-90
• All: 1 reference(s)