Il17a^tm2Yiw
Targeted Allele Detail

Summary

• Symbol: Il17a^tm2Yiw
• Name: interleukin 17A; targeted mutation 2, Yoichiro Iwakura
• MGI ID: MGI:5695091
• Synonyms: Il7^g
• Gene: Il17a Location: Chr1:20801129-20804720 bp, + strand Genetic Position: Chr1, 6.45 cM, cytoband A
• Alliance: Il17a^tm2Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223006
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An IRES-EGFP-poly A sequence was inserted immediately downstream of the endogenous Il17a translational stop codon. (J:223006)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17a Mutation: 24 strains or lines available

References

• Original: J:223006 Akitsu A, et al., IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vgamma6(+)gammadelta T cells. Nat Commun. 2015;6:7464
• All: 2 reference(s)