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Trem2em2Adiuj
Endonuclease-mediated Allele Detail
Summary
Symbol: Trem2em2Adiuj
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 2, MODEL-AD Center
MGI ID: MGI:5695000
Synonyms: Trem2 KO
Gene: Trem2  Location: Chr17:48653429-48659304 bp, + strand  Genetic Position: Chr17, 23.99 cM, cytoband C
Alliance: Trem2em2Adiuj page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe allele was generated by injecting Cas9 RNA and one guide sequence resulting in NHEJ-generated 175bp deletion that introduces a stop codon at amino acid 17. (J:101977)
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trem2 Mutation:  65 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory