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Trem2em2Adiuj
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Trem2em2Adiuj
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 2, MODEL-AD Center
MGI ID: MGI:5695000
Synonyms: Trem2 KO
Gene: Trem2  Location: Chr17:48346401-48352276 bp, + strand  Genetic Position: Chr17, 23.99 cM, cytoband C
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe allele was generated by injecting Cas9 RNA and one guide sequence resulting in NHEJ-generated 175bp deletion that introduces a stop codon at amino acid 17. (J:101977)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trem2 Mutation:  29 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory