Mmp14^tm1.1Otin
Targeted Allele Detail

Summary

• Symbol: Mmp14^tm1.1Otin
• Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1.1, Carlos Lopez-Otin
• MGI ID: MGI:5694577
• Synonyms: Mmp14^-
• Gene: Mmp14 Location: Chr14:54669055-54679913 bp, + strand Genetic Position: Chr14, 27.79 cM
• Alliance: Mmp14^tm1.1Otin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225609
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and a FRT-flanked neomycin cassette with a 3' loxP site were inserted downstream of exon 5. Recombination activities removed the neomycin cassette and exons 4 and 5. Western analysis confirmed the absence of protein expression. (J:225609)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp14 Mutation: 42 strains or lines available

References

• Original: J:225609 Gutierrez-Fernandez A, et al., Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid. EMBO J. 2015 Jul 14;34(14):1875-88
• All: 2 reference(s)