Mmp14^tm1Otin
Targeted Allele Detail

Summary

• Symbol: Mmp14^tm1Otin
• Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1, Carlos Lopez-Otin
• MGI ID: MGI:5694498
• Synonyms: Mmp14^floxed
• Gene: Mmp14 Location: Chr14:54669055-54679913 bp, + strand Genetic Position: Chr14, 27.79 cM
• Alliance: Mmp14^tm1Otin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225609
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and a FRT-flanked neomycin cassette with a 3' loxP site were inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette leaving exons 4 and 5 floxed. (J:225609)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp14 Mutation: 42 strains or lines available

References

• Original: J:225609 Gutierrez-Fernandez A, et al., Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid. EMBO J. 2015 Jul 14;34(14):1875-88
• All: 1 reference(s)