Ptk7^tm1.2Xwlu
Targeted Allele Detail

Summary

• Symbol: Ptk7^tm1.2Xwlu
• Name: PTK7 protein tyrosine kinase 7; targeted mutation 1.2, Xiaowei Lu
• MGI ID: MGI:5694062
• Gene: Ptk7 Location: Chr17:46875397-46940430 bp, - strand Genetic Position: Chr17, 22.9 cM, cytoband B3
• Alliance: Ptk7^tm1.2Xwlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199510
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked beta-geo cassette with a transmembrane domain and a 3' loxP site. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the beta-geo cassette. Cre-mediated recombination removed exons 3 through 5 floxed. Western blot analysis confirmed the absence of protein expression in E16.5 brains. (J:199510)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk7 Mutation: 58 strains or lines available

References

• Original: J:199510 Lee J, et al., PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium. Curr Biol. 2012 Jun 5;22(11):956-66
• All: 1 reference(s)