Nr1i2^{tm1.1(NR1I2)Kann}
Targeted Allele Detail

Summary

• Symbol: Nr1i2^{tm1.1(NR1I2)Kann}
• Name: nuclear receptor subfamily 1, group I, member 2; targeted mutation 1.1, Jun Kanno
• MGI ID: MGI:5693976
• Synonyms: hSXRki
• Gene: Nr1i2 Location: Chr16:38068711-38115211 bp, - strand Genetic Position: Chr16, 26.64 cM
• Alliance: Nr1i2^{tm1.1(NR1I2)Kann} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222347
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Nr1i2^{tm1.1(NR1I2)Kann} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NR1I2 (8856)

  Nr1i2

  (MGI:1337040)

• Mutation details: The sequence in exons 4 through 8 was replaced with the human sequence encoding the hinge region and ligand binding domain followed by a bovine growth hormone 3'UTR and floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. (J:222347)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1i2 Mutation: 33 strains or lines available

References

• Original: J:222347 Igarashi K, et al., Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence. J Toxicol Sci. 2012;37(2):373-80
• All: 1 reference(s)