Nhdlt1^{B6.129P2-Apoe-tm1Unc/J}
QTL Variant Detail

Summary

• QTL variant: Nhdlt1^{B6.129P2-Apoe-tm1Unc/J}
• Name: non-HDL cholesterol and triglyceride levels 1; B6.129P2-Apoe^tm1Unc/J
• MGI ID: MGI:5693631
• QTL: Nhdlt1 Location: Chr1:170675990-170676105 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: B6.129P2-Apoe^tm1Unc/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:153521

(Female C57BL/6.apoE-/- x male C3H/HeJ.apoE-/-)F1 mice were mated to produce 204 F2 mice in order to map QTL that influence neointimal formation in mice. C57BL/6.apoE-/- develop neointima lesions whereas C3H/HeJ.apoE-/- do not. This difference facilitated the QTL mapping of neointima lesions formation if a genome-wide scan using STS markers. A QTL , Nils1 segregated significantly with D12Mit144 ( 61. cM LOD 5.02) and explained 15% of the variance in lesion size. A suggestive QTL was found in chromosome 13 (LOD 2.67) associated with D13Mit250 and explained 8% of the variance.

Plasma non-HDL, cholesterol and triglyceride levels were also influenced by QTL using the same cross population. A QTL (Nhdlt1) was mapped in mouse Chromosome 1 associated withD1Mit270 (92.3 cM) with a LOD of 3.31 for non-HDL and 4.92 for Triglyceride. This QTL explained 9% of the variance for non-HDL and 11% of the varience for Triglyceride. Another Significant QTL with a LOD of 4.0 mapped near D12Mit97 and accounted for 9% of the varience for non-HDL. This QTL was indicated by the authors to overlap Nhdlq12. Sugestive loci for non-HDL was found near D4Mit192, and D15Mit161. A suggestive QTL for triglyceride mapped near D16Mit165

References

• Original: J:153521 Yuan Z, et al., Quantitative trait locus analysis of neointimal formation in an intercross between C57BL/6 and C3H/HeJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet. 2009 Jun 1;2(3):220-228
• All: 1 reference(s)