Cmv3^{C.C3-H2-k/LilMcdJ}
QTL Variant Detail

Summary

• QTL variant: Cmv3^{C.C3-H2-k/LilMcdJ}
• Name: cytomegalovirus resistance 3; C.C3-H2^k/LilMcdJ
• MGI ID: MGI:5693537
• QTL: Cmv3 Location: Chr6:128811857-137416927 bp Genetic Position: Chr6, cM position of peak correlated region/allele: 63.1 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: C.C3-H2^k/LilMcdJ

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:99390

The Authors investigated the mode of inheritance of the MA/My resistance to mouse cytomegalovirus (MCMV) in F1 and F2 progeny from crosses between MCMV-resistant MA/My and MCMV-susceptible BALB.K mice. Experimantal evidence indicated lod scores at the flanking markers D6Mit135 (proximal) and D6Mit291 (distal) were 20.8 and 18.7, respectively indentified Cmv3 in mouse Chromosome 6. This chromosomal region included Klrk1 and various Klra loci.

References

• Original: J:99309 Desrosiers MP, et al., Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection. Nat Genet. 2005 Jun;37(6):593-9
• All: 1 reference(s)