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QTL Variant Detail
QTL variant: Cmv3C.C3-H2-k/LilMcdJ
Name: cytomegalovirus resistance 3; C.C3-H2k/LilMcdJ
MGI ID: MGI:5693537
QTL: Cmv3  Location: Chr6:128811857-137416927 bp  Genetic Position: Chr6, cM position of peak correlated region/allele: 63.1 cM
QTL Note: genome coordinates based on the boundaries of the QTL region
Strain of Specimen:  C.C3-H2k/LilMcdJ
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


The Authors investigated the mode of inheritance of the MA/My resistance to mouse cytomegalovirus (MCMV) in F1 and F2 progeny from crosses between MCMV-resistant MA/My and MCMV-susceptible BALB.K mice. Experimantal evidence indicated lod scores at the flanking markers D6Mit135 (proximal) and D6Mit291 (distal) were 20.8 and 18.7, respectively indentified Cmv3 in mouse Chromosome 6. This chromosomal region included Klrk1 and various Klra loci.

Original:  J:99309 Desrosiers MP, et al., Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection. Nat Genet. 2005 Jun;37(6):593-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory