Sirt6^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Sirt6^{tm1c(EUCOMM)Wtsi}
• Name: sirtuin 6; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5692638
• Gene: Sirt6 Location: Chr10:81457621-81463631 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Sirt6^{tm1c(EUCOMM)Wtsi} page
• IMPC: Sirt6 gene page

Mutation origin

• Mutant Cell Line: EPD0256_5_F08
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Pgk_P
• Mutation details: Flp-mediated excision of the parental Sirt6^{tm1a(EUCOMM)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and the inserted lacZ reporter sequence, leaving behind the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sirt6 Mutation: 39 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 2 reference(s)