Ap4e1^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Ap4e1^{tm1c(KOMP)Wtsi}
• Name: adaptor-related protein complex AP-4, epsilon 1; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5692615
• Gene: Ap4e1 Location: Chr2:126850637-126909829 bp, + strand Genetic Position: Chr2, 61.76 cM
• Alliance: Ap4e1^{tm1c(KOMP)Wtsi} page
• IMPC: Ap4e1 gene page

Mutation origin

• Mutant Cell Line: EPD0025_5_A08
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: Flp-mediated excision of the parental Ap4e1^{tm1a(KOMP)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and the inserted lacZ reporter sequence, leaving behind the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ap4e1 Mutation: 59 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 1 reference(s)