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Ifnar1tm1.1Ees
Targeted Allele Detail
Summary
Symbol: Ifnar1tm1.1Ees
Name: interferon (alpha and beta) receptor 1; targeted mutation 1.1, Edward E Schmidt
MGI ID: MGI:5692160
Synonyms: Ifnar1fl
Gene: Ifnar1  Location: Chr16:91282126-91304329 bp, + strand  Genetic Position: Chr16, 52.98 cM
Alliance: Ifnar1tm1.1Ees page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229084
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (C57BL/6 x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting vector was designed to insert a self-excising FRT-Prm1pFlppol2Neo-FRT cassette and loxP site in intron 2, and a second loxP site in intron 3 of the gene. Facilitated self-excision of the cassette in the male germline and resulted in offspring with one FRT site and loxP site upstream of exon 3, and a second loxP site downstream of exon 3. (J:229084)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ifnar1 Mutation:  59 strains or lines available
References
Original:  J:229084 Prigge JR, et al., Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during Pneumocystis Lung Infection in Mice. J Immunol. 2015 Dec 1;195(11):5347-57
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory