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Sycp2ltm1Jw
Targeted Allele Detail
Nomenclature
Symbol: Sycp2ltm1Jw
Name: synaptonemal complex protein 2-like; targeted mutation 1, Jeremy Wang
MGI ID: MGI:5692068
Gene: Sycp2l  Location: Chr13:41267895-41327827 bp, + strand  Genetic Position: Chr13, 20.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:225272
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting vector was designed to replace exons 8-14 of the synaptonemal complex protein 2-like gene (Sycp2l) on chromosome 13 with a loxP-flanked PGK-neo cassette. The absence of protein expression was confirmed by Western blot analysis and immunostaining on ovarian extracts. (J:225272)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sycp2l Mutation:  16 strains or lines available
References
Original:  J:225272 Zhou J, et al., Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L. Hum Mol Genet. 2015 Nov;24(22):6505-14
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory