Fgf8^{tm1(cre/ERT2)Jlr}
Targeted Allele Detail

Summary

• Symbol: Fgf8^{tm1(cre/ERT2)Jlr}
• Name: fibroblast growth factor 8; targeted mutation 1, John Rubenstein
• MGI ID: MGI:5690222
• Synonyms: Fgf8^CreER
• Gene: Fgf8 Location: Chr19:45725237-45731354 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband C3-D
• Alliance: Fgf8^{tm1(cre/ERT2)Jlr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222259
• Parent Cell Line: PRX-B6T (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Fgf8^{tm1(cre/ERT2)Jlr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fgf8 (MGI:99604)

• Mutation details: An inducible cre recombinase gene (cre/ERT2), polyadenylation sequence and floxed neomycin resistance cassette replace the coding sequence in exon 1. (J:222259)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fgf8 (mouse) Summary of all recombinase alleles driven by Fgf8. Alliance mouse Fgf8 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf8 Mutation: 18 strains or lines available

References

• Original: J:222259 Hoch RV, et al., Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center. Neural Dev. 2015;10:8
• All: 3 reference(s)