Cath3^{C.129P2(B6)-Apoe-tm1Unc}
QTL Variant Detail

Summary

• QTL variant: Cath3^{C.129P2(B6)-Apoe-tm1Unc}
• Name: carotid atherosclerosis 3; C.129P2(B6)-Apoe^tm1Unc
• MGI ID: MGI:5689922
• QTL: Cath3 Location: unknown Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: C.129P2(B6)-Apoe^tm1Unc

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:197549

Linkage analysis was performed on 266 female (B6.129P2-Apoe^tm1Unc/J x C.129P2(B6)-Apoe^tm1Unc)F2 intercross mice using 130 SNP markers to identify QTL associated with susceptibility to athleroscotic carotid lesion. QTL mapping was performed using a nonparametric method.

QTL Cath3 maps to 18.99 - 59.69 cM on Chromosome 13 with a peak LOD score of 4.292 at 48.99 cM in linkage with athleroscotic carotid lesion incidence. B6.129P2-Apoe^tm1Unc/J alleles confer increased susceptibility to athleroscotic carotid lesion with an additive mode of inheritance.

References

• Original: J:197549 Rowlan JS, et al., New quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains. Physiol Genomics. 2013 Apr 16;45(8):332-42
• All: 1 reference(s)